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Arizona Cardinals vs San Francisco 49ers

September 27, 2026 · 4:05 PM ET · Levi's Stadium
ARI — · SF 1-0

SportsFBI Model

Projects San Francisco 49ers to win — 72% confidence

Market agrees (-15pp) Market-implied score: SF 29 · ARI 18 Blowout chance (14+ margin): 46%

SF Home field advantage

SF Home team off bye

SF Away team key injuries

Betting Lines DraftKings

Spread

ARI +11.5 (-110)

SF -11.5 (-110)

Total (O/U)

Over 46.5 (-110)

Under 46.5 (-110)

Moneyline

ARI +490

SF -675

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